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apalutamide will lower the level or result of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with medications that are CYP3A4 substrates can lead to lessen exposure to those drugs.Will it make me so sleepy I can not operate? After you init